abstract：:A partially purified extract from American ginseng has been shown to have anticonvulsant activity. To identify the active components in this extract, the activities of the individual ginsenosides (Rb(1), Rb(3) and Rd), mixtures of the purified ginsenosides and a newly prepared Rb fraction were determined. One hour aft...

journal_title：Epilepsy research

authors： Lian XY,Zhang Z,Stringer JL

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:To evaluate the influence of aging on the pharmacokinetics of valproic acid (VPA) at steady-state and on the susceptibility of VPA metabolism to enzyme induction by antiepileptic comedication. METHODS:The database of the therapeutic drug monitoring service of a large neurological hospital was searched to ident...

journal_title：Epilepsy research

authors： Fattore C,Messina S,Battino D,Croci D,Mamoli D,Perucca E

更新日期：2006-08-01 00:00:00

abstract：:Benign myoclonic epilepsy in infancy is a rare syndrome with just over 100 cases reported since the first syndromic description by Dravet and Bureau [Dravet, C., Bureau, M., 1981. The benign myoclonic epilepsy of infancy. Rev. Elecroencephalogr. Neurophysiol. Clin. 11, 438-444]. This includes 23 infants with reflex my...

journal_title：Epilepsy research

authors： Zuberi SM,O'Regan ME

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Anticonvulsant hypersensitivity syndrome (AHS) is one of the most severe forms of drug eruption with potentially lethal, and multiorgan involvement. Recently, it has been suggested that Human Herpesvirus (HHV) infection has been involved in this syndrome, although the pathogenesis of this syndrome remains st...

journal_title：Epilepsy research

authors： Oskay T,Karademir A,Ertürk OI

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To assess subjective seizure anticipation in patients with focal and generalized epilepsy. METHODS:Five hundred consecutively recruited out-patients (251 male, 249 female, mean age 38.1 year) from three German tertiary epilepsy referral centres filled out questionnaires regarding subjective anticipation of sei...

journal_title：Epilepsy research

authors： Schulze-Bonhage A,Kurth C,Carius A,Steinhoff BJ,Mayer T

更新日期：2006-07-01 00:00:00

abstract：:There is a remarkable array of new chemical entities in the current antiepileptic drug (AED) development pipeline. In some cases, the compounds were synthesized in an attempt improve upon the activity of marketed AEDs. In other cases, the discovery of antiepileptic potential was largely serendipitous. Entry into the p...

journal_title：Epilepsy research

authors： Rogawski MA

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:Measurement of local cerebral blood flow (LCBF) is routinely used to locate the areas involved in the generation and spread of seizures in epileptic patients. Since the spatial distribution and extent of ictal LCBF depends on the epileptogenic network, but also on the timing of injection of tracer, we used a ...

journal_title：Epilepsy research

authors： Chassagnon S,André V,Koning E,Ferrandon A,Nehlig A

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:The aim of the present study is to verify whether patients with partial epilepsy receiving levetiracetam (LEV) as an add-on treatment show an improvement in cognitive function. METHODS:A neuropsychological battery of tests was administered to 35 patients with partial epilepsy before the assumption of LEV and a...

journal_title：Epilepsy research

authors： Piazzini A,Chifari R,Canevini MP,Turner K,Fontana SP,Canger R

更新日期：2006-03-01 00:00:00

abstract：:Recent years have witnessed an increased interest from pediatric neurologists, neuropediatricians, epileptologists and general neurologists in the use of the ketogenic diet (KD) for the management of refractory epilepsies, particularly in children and adolescents. This article summarizes current knowledge on various i...

journal_title：Epilepsy research

authors： Freeman J,Veggiotti P,Lanzi G,Tagliabue A,Perucca E,Institute of Neurology IRCCS C. Mondino Foundation.

更新日期：2006-02-01 00:00:00

abstract：:Zonisamide (Zonegran), a novel antiepileptic drug (AED) approved recently in Europe as adjunctive therapy for refractory partial seizures in adults, has been used extensively in Japan and the United States. A substantial body of clinical experience has accumulated over a 14-year period, allowing the properties and pha...

journal_title：Epilepsy research

authors： Baulac M

更新日期：2006-02-01 00:00:00

abstract：:We analyzed preoperative ictal SPECT results from 18 frontal lobe epilepsy patients who underwent epilepsy surgery (mean age 22.9 years). Seizure onset at implanted subdural electrodes was defined as the epileptic focus in 16 of 18 patients. In two additional patients, the resected area on postoperative magnetic reson...

journal_title：Epilepsy research

authors： Fukuda M,Masuda H,Honma J,Kameyama S,Tanaka R

更新日期：2006-02-01 00:00:00

abstract：:Special issues are related to AED testing in several populations. Pharmacokinetics, pharmacodynamics and underlying neurochemistry and developing systems require specific testing in appropriate infants with refractory seizures. EEG monitoring is an essential part of seizure definition and recognition, making it a nece...

journal_title：Epilepsy research

authors： Pellock J

更新日期：2006-01-01 00:00:00

abstract：:Evidence-based treatment guidelines and practice parameters have been developed in most areas of medicine. They are important because insurance companies, formulary managers, and health maintenance organizations rely on guidelines for formulary and coverage decisions. The methodology for practice parameter development...

journal_title：Epilepsy research

authors： French JA

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:This retrospective study addresses the cost-effectiveness of add-on therapy with lamotrigine in clinical practice. METHODS:Two years' observational data of 165 patients were used. Seizure frequency, adverse effects and direct medical costs were recorded for the year before and the year after the start of lam...

journal_title：Epilepsy research

authors： Knoester PD,Boendermaker AJ,Egberts AC,Hekster YA,Keyser A,Severens JL,Renier WO,Deckers CL

更新日期：2005-12-01 00:00:00

abstract：:Interruption of neurogenesis and/or neuronal migration produces brain dysplasia modifying susceptibility to epileptic seizures in adulthood. The course of neurogenesis has a strictly defined time-table. Consequently, the developmental stage at which the interruption occurs determines what functional subsystem potentia...

journal_title：Epilepsy research

authors： Setkowicz Z,Janicka D,Kowalczyk A,Turlej A,Janeczko K

更新日期：2005-12-01 00:00:00

abstract：:Increased excitatory amino acid transmission and decreased GABAergic inhibitory responses seem to be important mechanisms in the genesis of convulsions, where reactive oxygen species (ROS) have recently been suggested to play a critical role. Therefore, administration of antioxidants may be potentially beneficial for ...

journal_title：Epilepsy research

authors： Ribeiro MC,de Avila DS,Schneider CY,Hermes FS,Furian AF,Oliveira MS,Rubin MA,Lehmann M,Krieglstein J,Mello CF

更新日期：2005-08-01 00:00:00

abstract：RATIONALE:Epilepsy is the most common serious neurological condition in the world, and an important cause of mortality and disability in developing countries. Because epidemiological and clinical characteristics of epilepsy vary by region, it is important to know the peculiarities of epilepsy in this area of the Americ...

journal_title：Epilepsy research

authors： Burneo JG,Tellez-Zenteno J,Wiebe S

更新日期：2005-08-01 00:00:00

abstract：:The ketogenic diet (KD) increased the expression of calbindin-D(28k) (CB) in the interneurons of the hippocampus compared with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes were found in the KD-fed mice compared with those of the ND-fed mice. These...

journal_title：Epilepsy research

authors： Noh HS,Kang SS,Kim DW,Kim YH,Park CH,Han JY,Cho GJ,Choi WS

更新日期：2005-07-01 00:00:00

abstract：:Benign childhood epilepsy with occipital paroxysms is classified among childhood benign partial epilepsies. The absence of neurological and neuropsychological deficits has long been considered as a prerequisite for a diagnosis of benign childhood partial epilepsy. Much evidence has been reported in literature in the l...

journal_title：Epilepsy research

authors： Germanò E,Gagliano A,Magazù A,Sferro C,Calarese T,Mannarino E,Calamoneri F

更新日期：2005-05-01 00:00:00

abstract：:The purpose of this study was to determine the influence of levetiracetam on the steady-state serum concentrations of other commonly used antiepileptic drugs (AEDs). Serum AED concentrations were measured at baseline and after adjunctive therapy with levetiracetam (1000-4000 mg/day) or placebo in four phase III trials...

journal_title：Epilepsy research

authors： Gidal BE,Baltès E,Otoul C,Perucca E

更新日期：2005-03-01 00:00:00

abstract：:Bupropion, a unique, non-nicotine smoking cessation aid and an effective antidepressant, is well known to produce seizures following overdosing in humans. However, the experimental background for the usefulness of antiepileptic drugs in the protection against bupropion-induced convulsions has not been established yet....

journal_title：Epilepsy research

authors： Tutka P,Mróz T,Klucha K,Piekarczyk M,Wielosz M

更新日期：2005-03-01 00:00:00

abstract：:Prevention of epileptogenesis after brain insults, such as status epilepticus (SE), head trauma, or stroke, remains a challenge. Even if epilepsy cannot be prevented, it would be beneficial if the pathologic process could be modified to result in a less severe disease. We examined whether early discontinuation of SE r...

journal_title：Epilepsy research

authors： Pitkänen A,Kharatishvili I,Narkilahti S,Lukasiuk K,Nissinen J

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Proton magnetic resonance spectroscopy ((1)H MRS) has been proposed as a lateralizing method for the presurgical evaluation of patients with medically intractable temporal lobe epilepsy (TLE). Studies have shown correlations between temporal lobe (TL) NAA and seizure frequency, and TL NAA/Cr and the durati...

journal_title：Epilepsy research

authors： Burneo JG,Knowlton RC,Faught E,Martin R,Sawrie S,Kuzniecky RI

更新日期：2004-12-01 00:00:00

abstract：:Neuropeptide Y (NPY) and galanin are neuropeptides that are regulated by energy states and are also anticonvulsant. We tested the hypothesis that the anticonvulsant efficacy of the ketogenic diet (KD) is mediated by increased expression of NPY and galanin via alterations in food intake and energy metabolism. In situ h...

journal_title：Epilepsy research

authors： Tabb K,Szot P,White SS,Liles LC,Weinshenker D

更新日期：2004-11-01 00:00:00

abstract：:The purpose of this study is to propose and investigate a new approach for discriminating between focal and non-focal hemispheres in intractable temporal lobe epilepsy, based on applying multivariate time series analysis to the discharge-free background brain activity observed in nocturnal electrocorticogram (ECoG) ti...

journal_title：Epilepsy research

authors： Miwakeichi F,Galka A,Uchida S,Arakaki H,Hirai N,Nishida M,Maehara T,Kawai K,Sunaga S,Shimizu H

更新日期：2004-09-01 00:00:00

abstract：:Clinical and epidemiological studies have repeatedly demonstrated that a subset of patients with epilepsy have progressive syndromes with increasing seizure frequency and cumulative adverse effects despite optimal anticonvulsant therapy. Recent longitudinal imaging studies and long-term neuropsychological studies have...

journal_title：Epilepsy research

authors： Sutula TP

更新日期：2004-07-01 00:00:00

abstract：AIMS:To investigate the pathophysiology of pharmacoresistant epilepsies with cryptogenic generalised tonic-clonic seizures (GTCS) from infancy. METHODS:18F-Deoxy-Glucose-Positron Emission Tomography 18FDG-PET) with statistical parametric mapping (SPM). Inclusion criteria were: pharmacoresistant chronic epilepsy with G...

journal_title：Epilepsy research

authors： Korinthenberg R,Bauer-Scheid C,Burkart P,Martens-Le Bouar H,Kassubek J,Juengling FD

更新日期：2004-06-01 00:00:00

abstract：:We evaluated the efficacy of vagus nerve stimulation (VNS) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a validated model for absence epilepsy. In the first experiment, we investigated whether VNS applied at seizure onset can interrupt spike and wave discharges (SWD). In the second experiment, we investig...

journal_title：Epilepsy research

authors： Dedeurwaerdere S,Vonck K,Claeys P,Van Hese P,D'Havé M,Grisar T,Naritoku D,Boon P

更新日期：2004-04-01 00:00:00

abstract：:Overexpression of multidrug efflux transporters such as P-glycoprotein (Pgp; ABCB1) or multidrug resistance proteins (MRPs; ABCC) in the blood-brain barrier has recently been suggested to explain, at least in part, pharmacoresistance in epilepsy, which affects about 30% of all patients with this common brain disorder....

journal_title：Epilepsy research

authors： Potschka H,Baltes S,Löscher W

更新日期：2004-02-01 00:00:00

abstract：:Increased prevalence of autoantibodies has been suggested in patients with epilepsy. This study determined the presence of autoantibodies in a representative cohort of 960 patients with epilepsy. The frequency of antinuclear antibodies (ANA), immunoglobulin G class anticardiolipin antibodies (aCL) and anti-B2-glycopro...

journal_title：Epilepsy research

authors： Ranua J,Luoma K,Peltola J,Haapala AM,Raitanen J,Auvinen A,Isojärvi J

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Lamotrigine (LTG) is approved for monotherapy following withdrawal from enzyme-inducing antiepileptic drugs. LTG is also frequently used in combination with sodium valproate (VPA), and withdrawal to monotherapy in this setting is also frequently desirable. Given the known pharmacokinetic interaction between t...

journal_title：Epilepsy research

authors： Gidal BE,Sheth R,Parnell J,Maloney K,Sale M

更新日期：2003-12-01 00:00:00

abstract：:Young adult and aged male Fisher 344 rats underwent kainate-induced convulsive status epilepticus (SE) for 4 h prior to sacrifice to determine potential aging-related differences in the effect of prolonged SE on the expression of hippocampal voltage-gated calcium channels (VGCCs). Immunohistochemistry was performed on...

journal_title：Epilepsy research

authors： Kelly KM,Ikonomovic MD,Abrahamson EE,Kharlamov EA,Hentosz TM,Armstrong DM

更新日期：2003-11-01 00:00:00

abstract：:The idiopathic generalized epilepsies (IGE), for which a genetic cause is widely accepted, account for 20-30% of all epilepsies. Mapping these epilepsies is difficult, but progress in the positional cloning of idiopathic epilepsy genes responsible for monogenic forms provide emerging evidence that many idiopathic epil...

journal_title：Epilepsy research

authors： Sáez-Hernández L,Peral B,Sanz R,Gómez-Garre P,Ramos C,Ayuso C,Serratosa JM

更新日期：2003-10-01 00:00:00

abstract：:Glutamatergic ionotropic and metabotropic receptor modulators have been shown to produce anticonvulsant activity in a number of animal seizure models, e.g. maximal electroshock (MES) and DBA/2 sensory-induced seizures. The 6 Hz model of partial seizures is an alternative low frequency, long duration stimulation paradi...

journal_title：Epilepsy research

authors： Barton ME,Peters SC,Shannon HE

更新日期：2003-09-01 00:00:00

abstract：RATIONALE:In a search for potential supplements or alternatives to the pharmacological treatment of epilepsy, we examined the effects of static magnetic fields on audiogenic seizures of DBA/2 mice. METHODS:Two strains of DBA/2 mice were subjected to auditory stimulation that resulted sequentially in wild running, loss...

journal_title：Epilepsy research

authors： McLean MJ,Engström S,Holcomb RR,Sanchez D

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:To determine the relative bioavailability and tolerability of a topiramate (TPM) suspension after rectal administration. DESIGN/METHOD:Seven healthy men and five healthy non-pregnant women were enrolled. A 100 or 200 mg tablet of TPM was given orally and a 200 mg dose was given rectally in a randomized, open...

journal_title：Epilepsy research

authors： Conway JM,Birnbaum AK,Kriel RL,Cloyd JC

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Valproate is used widely for the treatment of epilepsy but has been associated with hyperandrogenism, hyperinsulinemia, and dyslipidemia. The mechanism for these associations is unknown, but they have been hypothesized to be secondary to valproate-associated weight gain. This study was conducted to test the ...

journal_title：Epilepsy research

authors： Morrell MJ,Isojärvi J,Taylor AE,Dam M,Ayala R,Gomez G,O'Neill F,Tennis P,Messenheimer J

更新日期：2003-05-01 00:00:00

abstract：:Post-stroke seizures occur in 5-20% of patients. Modeling of stroke-induced seizures in animals provides a useful tool for investigating the molecular basis of epileptogenesis and for developing therapies for stroke patients at increased risk for epileptogenesis. The questions addressed in the study were: (1) Do rats ...

journal_title：Epilepsy research

authors： Karhunen H,Pitkänen A,Virtanen T,Gureviciene I,Pussinen R,Ylinen A,Sivenius J,Nissinen J,Jolkkonen J

更新日期：2003-04-01 00:00:00

abstract：:In the brain, injury-induced gliosis and axonal sprouting have been regarded as age-dependent repairing processes with, unfortunately, epileptogenic effects. The present study examines whether brains injured at different developmental stages become more or less susceptible to experimentally-induced status epilepticus....

journal_title：Epilepsy research

authors： Setkowicz Z,Janeczko K

更新日期：2003-03-01 00:00:00

abstract：:Recently, mutations of KCNQ2 or KCNQ3, members of the KCNQ-related K(+)-channel (KCNQ-channel) family, were identified as cause of benign familial neonatal convulsions (BFNC). However, the exact pathogenic mechanisms of age-dependent development and spontaneous remission of BFNC remain to be elucidated. To clarify the...

journal_title：Epilepsy research

authors： Okada M,Zhu G,Hirose S,Ito KI,Murakami T,Wakui M,Kaneko S

更新日期：2003-02-01 00:00:00